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In vitro experiments showed that L-asparaginase induced apoptosis in sarcoma and suppressed angiogenic potential as well as inducing autophagy in ovarian cancer [48, 77]

Although the SPAAC DBCO-azide reaction is relatively slow, it proceeds several orders of magnitude faster than the competing glutathione-mediated reduction of azides in biological systems, making this competing process less disruptive to the overall fluorescence readout in our CHAMP assays

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